Table 3 Weighted sum score and polygenic risk score of each family member.

Family ID	Individual ID	Disease status	Weighted sum score*	Polygenic risk score	Age^#
FMS01	FMS0119	Affected	1.57	1.35	54
	FMS0124	Affected	2.19	2.28	30
	FMS0132	Affected	2.26	2.70	44
	FMS0157	Affected	1.25	0.58	43
	FMS0121	Unaffected	0.09	− 1.61	56
	FMS0123	Unaffected	− 0.45	− 0.94	33
FMS02	FMS0207	Affected	1.21	1.02	31
	FMS0208	Affected	2.12	1.55	34
	FMS0209	Affected	0.80	1.09	25
	FMS0203	Unaffected	1.64	2.02	68
	FMS0206	Unaffected	0.78	0.26	59
	FMS0210	Unaffected	1.48	1.38	39
FMS03	FMS0306	Affected	− 0.63	1.00	62
	FMS0307	Affected	0.87	0.24	36
	FMS0318	Affected	1.59	1.71	25
	FMS0305	Unaffected	− 0.16	− 1.42	65
	FMS0308	Unaffected	− 1.18	− 1.51	44
	FMS0309	Unaffected	− 1.21	− 0.52	39
FMS04	FMS0411	Affected	− 0.28	0.67	58
	FMS0412	Affected	− 0.72	1.45	56
	FMS0429	Affected	− 1.10	− 0.85	42
	FMS0430	Affected	− 0.61	− 0.32	40
	FMS0431	Unaffected	0.57	0.69	35
	FMS0432	Unaffected	− 0.40	− 1.15	38
FMS05	FMS0503	Affected	0.61	− 1.20	56
	FMS0504	Affected	1.32	− 0.59	54
	FMS0522	Affected	− 0.17	− 0.11	38
	FMS0501	Unaffected	1.30	0.31	90
	FMS0506	Unaffected	1.72	0.15	69
	FMS0511	Unaffected	1.69	− 0.35	52
	FMS0524	Unaffected	− 0.17	− 0.73	43
FMS07	FMS0707	Affected	0.62	1.19	44
	FMS0719	Affected	− 0.04	1.14	40
	FMS0721	Affected	1.20	0.07	41
	FMS0704	Unaffected	0.01	− 0.59	69
	FMS0708	Unaffected	− 0.93	0.13	49
	FMS0709	Unaffected	− 1.16	0.05	47

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