Figure 1 | Scientific Reports

Figure 1

From: Network analysis reveals that the tumor suppressor lncRNA GAS5 acts as a double-edged sword in response to DNA damage in gastric cancer

Figure 1

Gene regulatory network of lncRNA-GAS5 for the GC. Arrows indicate activations, and hammer-head arcs indicate inhibitions, respectively. The blue rectangular node represents lncRNA-GAS5, the yellow rectangular node represents miR-34c, and the red one represents DNA damage which is the input to the Boolean model. Dashed hammer-head arcs represent the targets of miR-34c highlighted by orange-colored oval nodes while other proteins are in grey-colored nodes. Model outputs are proliferation (in the lack of DNA damage) or cell cycle arrest, or apoptosis in the occupation of DNA damage.

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