Table 4 Risk of non-tuberculosis mycobacterial pulmonary disease in subgroups according to age, sex, presence of diabetes mellitus, respiratory disease, any malignancy, and connective tissue diseases.

From: Severity of underweight affects the development of nontuberculous mycobacterial pulmonary disease; a nationwide longitudinal study

 

Subgroup

 

Severity of underweight

P for interaction

Normal weight

Mild (HRs, 95% CI)

Moderate (HRs, 95% CI)

Severe (HRs, 95% CI)

Age

 < 65

1(ref.)

2.51 (2.27, 2.76)

4.23 (3.56, 5.03)

5.55 (4.28, 7.20)

0.013

 ≥ 65

1 (ref.)

2.89 (2.56, 3.26)

3.92 (3.20, 4.80)

5.41 (4.19, 6.98)

Sex

Men

1 (ref.)

2.80 (2.51, 3.12)

4.76 (3.99, 5.68)

5.41 (4.18, 7.00)

 < 0.001

Women

1 (ref.)

1.93 (1.74, 2.15)

2.54 (2.09, 3.09)

3.58 (2.77, 4.62)

Respiratory diseases

No

1 (ref.)

2.38 (2.17, 2.61)

3.73 (3.16, 4.40)

4.80 (3.77, 6.11)

0.308

Yes

1 (ref.)

2.32 (2.04, 2.64)

3.21(2.59, 3.97)

4.01 (3.04, 5.27)

Diabetes mellitus

No

1 (ref.)

2.35 (2.17, 2.54)

3.50 (3.06, 4.01)

4.37 (3.62, 5.26)

0.974

Yes

1 (ref.)

2.30 (1.64, 3.21)

3.48 (1.96, 6.21)

4.23 (1.99, 9.02)

Any malignancy

No

1 (ref.)

2.36 (2.19, 2.55)

3.46 (3.03, 3.96)

4.48 (3.73, 5.37)

0.185

Yes

1 (ref.)

1.83 (1.17, 2.87)

4.57 (2.53, 8.26)

1.10 (0.15, 7.93)

Connective tissue diseases

No

1 (ref.)

2.33 (2.16, 2.52)

3.53 (3.10, 4.03)

4.21 (3.50, 5.07)

0.088

Yes

1 (ref.)

3.20 (1.77, 5.79)

1.74 (0.42, 7.26)

12.63 (4.90, 32.55)

  1. Adjusted for age, sex, smoking, alcohol intake, regular exercise, respiratory diseases, solid cancer, hematologic malignancy, transplantation, AIDS, GERD, connective tissue diseases, diabetes mellitus.
  2. HR hazards ratios, 95% CI 95% confidence interval.
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