Table 2 Multivariate regression analysis of macular VD measurements.

From: Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort

Covariates

Dependent variables

Coefficient

t

Significance

Beta

Sex

VD nasal

0.03

0.06

0.96

0.01

VD superior

0.10

0.16

0.88

0.01

VD temporal

0.56

1.25

0.21

0.05

VD inferior

0.70

1.12

0.27

0.05

Age

VD nasal

− 0.05

− 1.37

0.17

− 0.07

VD superior

− 0.06

− 1.46

0.15

− 0.07

VD temporal

− 0.05

− 1.82

0.07

− 0.09

VD inferior

− 0.02

− 0.40

0.70

− 0.02

Education

VD nasal

− 0.11

− 1.78

0.08

− 0.08

VD superior

0.01

0.14

0.89

0.01

VD temporal

− 0.05

− 1.00

0.32

− 0.05

VD inferior

− 0.06

− 0.89

0.38

− 0.04

Hypertension

VD nasal

− 0.25

− 0.47

0.64

− 0.02

VD superior

0.12

0.20

0.84

0.01

VD temporal

0.15

0.34

0.73

0.01

VD inferior

0.59

0.93

0.35

0.04

Diabetes mellitus

VD nasal

− 0.38

− 0.56

0.58

− 0.02

VD superior

0.88

1.15

0.25

0.05

VD temporal

0.33

0.57

0.57

0.02

VD inferior

1.57

1.95

0.05

0.08

Heart disease

VD nasal

− 0.64

− 1.09

0.27

− 0.04

VD superior

0.33

0.51

0.61

0.02

VD temporal

0.44

0.88

0.38

0.04

VD inferior

− 2.11

− 3.06

0.01*

− 0.13

Stroke

VD nasal

0.19

0.21

0.83

0.01

VD superior

− 1.32

− 1.36

0.18

− 0.06

VD temporal

− 0.46

− 0.63

0.53

− 0.03

VD inferior

0.99

0.96

0.34

0.04

Diagnostic groups: CU vs MCI-AD

VD nasal

0.87

0.98

0.33

0.05

VD superior

0.64

0.65

0.52

0.04

VD temporal

1.77

2.36

0.02*

0.13

VD inferior

− 1.59

− 1.52

0.13

− 0.08

Diagnostic groups: CU vs MCI-Va

VD nasal

0.07

0.07

0.94

0.01

VD superior

− 0.22

− 0.21

0.84

− 0.01

VD temporal

0.50

0.64

0.52

0.04

VD inferior

− 2.58

− 2.34

0.02*

− 0.13

Diagnostic groups: CU vs ADD

VD nasal

0.27

0.31

0.76

0.02

VD superior

0.57

0.59

0.55

0.04

VD temporal

1.23

1.68

0.09

0.11

VD inferior

− 1.04

− 1.03

0.31

− 0.07

Diagnostic groups: CU vs VaD

VD nasal

0.85

0.73

0.47

0.04

VD superior

1.40

1.07

0.29

0.06

VD temporal

1.29

1.30

0.19

0.07

VD inferior

0.09

0.07

0.95

0.01

  1. The multivariate regression analysis included the following adjusting factors: age, sex, years of education, hypertension, diabetes mellitus, heart disease and stroke.
  2. ADD = probable Alzheimer´s disease dementia; CU = cognitively unimpaired; MCI-AD = mild cognitive impairment due to Alzheimer´s disease; MCI-Va = mild cognitive impairment due to cerebrovascular pathology; VaD = vascular dementia; VD = vessel density.
  3. Significance was set up at p < 0.05.
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