Figure 7
From: ROCK1/MLC2 inhibition induces decay of viral mRNA in BPXV infected cells
Evaluation of antiviral drug resistance against Thiazovivin. BPXV was sequentially passaged (P) fifty times in the medium containing 0.5 μg/ml of Thiazovivin or equivalent volumes of DMSO. The original virus stock (P0), P50-Thiazovivin and P50-Control viruses were used to infect Vero cells, in triplicates, at an MOI of 0.1 and treated with either 1 μg/ml of Thiazovivin or equivalent volumes of DMSO. The virus released in the supernatant at 48 hpi was quantified by plaque assay. Error bars indicate SD. Pair-wise statistical comparisons were performed using Student’s t test (***P < 0.001).
