Figure 1
Blood cell profiles in mice 12–18 months post-irradiation. (A) Lymphocytes (LYM) were enumerated using flow cytometry as CD41− and CD11b− cells in the peripheral blood leukocytes and compared between radiation-exposed (N = 36) and non-exposed (N = 11) mice. The LYM percentages were significantly different (P < 0.01) based on linear-regression analysis after adjusting for age and sex. The blue and red dots represent male and female animals, respectively. Inter-quartile ranges are shown with gray-shaded areas. (B) Myeloid cell percentages (MYE, %) in the peripheral blood leukocytes were evaluated with CD41− and CD11b+ populations, including Ly6C-low granulocytes and Ly6C-high monocytes. The same statistical analysis indicated a significant difference between radiation-exposed (N = 36) and non-exposed (N = 11) mice (P < 0.01). (C) RDW values of peripheral blood erythrocytes were measured using a hematological autoanalyzer in mice after irradiation. Three data were missing for irradiated mice because of sampling errors. The RDW values significantly differed between radiation-exposed (N = 33) and non-exposed (N = 11) mice (P < 0.01). RDW, red blood cell distribution width.
