Table 4 Uni- and multivariable Cox regression analysis for overall survival.

	Univariable analysis		Multivariable analysis
	Hazard-ratio (95% confidence interval)	*p value	Hazard-ratio (95% confidence interval)	p value
Age ≥ 65 years	0.992 (0.548–2.154)	0.802
BMI ≥ 25	0.858 (0.494–1.490)	0.586
Sex male	2.005 (0.939–4.281)	0.072	3.128 (1.159–8.444)	0.024
ASA ≥ 3	1.465 (0.800–2.684)	0.216
Cirrhosis yes	1.468 (0.843–2.557)	0.175
Preoperative labMELD ≥ 8	2.121 (1.046–4.300)	0.037	2.200 (1.030–4.699)	0.042
Outside milan criteria yes	2.020 (0.837–4.876)	0.118
Preoperative AFP ≥ 10 (µg/l)	1.187 (0.396–3.558)	0.760
Preoperative AST ≥ 40 (U/l)	1.425 (0.707–2.873)	0.323
Preoperative ALT ≥ 40 (U/l)	1.448 (0.776–2.704)	0.242
Preoperative Albumin ≤ 40 (g/l)	1.438 (0.667–3.102)	0.354
Largest tumor diameter ≥ 50 mm	1.800 (0.882–3.769)	0.119
Preoperative TACE yes	1.320 (0.317–5.498)	0.703
Preoperative PVE yes	1.734 (0.617–4.877)	0.297
Intraoperative FFP yes	2.054 (1.056–3.961)	0.034	1.499 (0.600–3.748)	0.386
Intraoperative RBC yes	2.700 (1.33–5.469)	0.002	1.740 (0.584–5.189)	0.320
Extended resection yes	1.309 (0.697–2.461)	0.402
Vascular Reconstruction yes	0.960 (0.131–7.049)	0.968
Duration Surgery ≥ 210 min	0.885 (0.508–1.542)	0.667
Not R0-resection yes	1.977 (0.898–4.354)	0.091	2.103 (0.842–5.254)	0.111
Postoperative Complications (CD ≥ 3a¹)	1.381 (0.680–2.806)	0.371
Osteopenia (BMD) yes	2.589 (1.173–5.715)	0.019	7.743 (2.186–27.431)	0.002

Results of the Cox regression analysis were given as Hazard-ratios with 95% confidence interval.
¹Refers to Clavien et al.²⁶.
BMI Body mass index; ASA American Society of Anesthesiologists; MELD model for end-stage liver disease; AFP alphafetoprotein; AST Aspartate aminotransferase; ALT Alanine aminotransferase; TACE Transarterial chemoembolization; PVE Portal venous embolization; FFP Fresh frozen plasma; RBC Red blood cell unit; CD Clavien-Dindo classification; BMD Bone mineral density.
Significant values are in [bold].

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