Table 5 Uni- and multivariable Cox regression analysis for disease-free survival.

	Univariable analysis		Multivariable analysis
	Hazard-ratio (95% Confidence Interval)	*p value	Hazard-ratio (95% Confidence Interval)	p value
Age ≥ 65 years	0.632 (0.335–1.193)	0.157
BMI ≥ 25	1.004 (0.532–1.894)	0.991
Sex Male	1.126 (0.585–2.168)	0.722
ASA ≥ 3	1.005 (0.529–1.909)	0.988
Cirrhosis yes	1.397 (0.741–2.631)	0.301
Preoperative labMELD ≥ 8	1.395 (0.716–2.717)	0.328
Outside Milan criteria yes	4.283 (1.151–12.111)	0.006	4.357 (1.493–12.714)	0.015
Preoperative AFP ≥ 10 (µg/l)	1.415 (0.587–3.412)	0.440
Preoperative AST ≥ 40 (U/l)	2.274 (1.147–4.509)	0.019	1.618 (0.522–5.020)	0.405
Preoperative ALT ≥ 40 (U/l)	2.154 (1.022–4.541)	0.044	2.199 (0.700–6.905)	0.177
Preoperative Albumin ≤ 40 (g/l)	1.290 (0.628–2.648)	0.488
Largest tumor diameter ≥ 50 mm	1.672 (0.853–3.279)	0.646
Preoperative TACE yes	0.744 (0.101–5.464)	0.772
Preoperative PVE yes	3.201 (0.960–10,677)	0.058	1.681 (0.188–15.048)	0.642
Intraoperative FFP yes	2.025 (1.076–3.809)	0.029	3.693 (1.515–9.003)	0.004
Intraoperative RBC yes	1.818 (0.886–3.728)	0.103
Extended Resection yes	1.272 (0.621–2.604)	0.511
Vascular Reconstruction yes	0.691 (0.091–4.893)	0.691
Duration Surgery ≥ 210 min	0.610 (0.318–1.171)	0.137
Not R0-Resection yes	2.404 (1.168–4.947)	0.017	3.356 (1.223–9.206)	0.019
Postoperative Complications (CD ≥ 3a¹)	0.719 (0.331–1.563)	0.406
Osteopenia (BMD) yes	2.480 (1.169–5.260)	0.018	2.053 0.793–5.314)	0.138

Results of the Cox regression analysis were given as Hazard-ratios with 95% confidence interval.
¹Refers to Clavien et al.²⁶.
BMI Body mass index; ASA American Society of Anesthesiologists; MELD model for end-stage liver disease; AFP alphafetoprotein; AST Aspartate aminotransferase; ALT Alanine aminotransferase; TACE Transarterial chemoembolization; PVE Portal venous embolization; FFP Fresh frozen plasma; RBC Red blood cell unit; CD Clavien-Dindo classification; BMD Bone mineral density.
Significant values are in [bold].

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