Figure 1

(a) Normative map of sgACC functional connectivity, indicating strongest areas of correlation (orange-yellow), and anti-correlation (blue). Strong normative sgACC anti-correlation is prominent at a DLPFC site (red arrow) which has previously been shown to be an effective rTMS target in major depression5,6. (b) Individualized winner-take-all maps of DAN (blue) and DMN (yellow) for two representative example subjects. Red arrows depict the group-mean stimulation site, which shows differing spatial relationships with DAN in the two patients (c) Example of overlap between individualized RSNM DAN/DMN maps (from patient 2) and normative sgACC seed map.