Figure 5 | Scientific Reports

Figure 5

From: Individualized precision targeting of dorsal attention and default mode networks with rTMS in traumatic brain injury-associated depression

Figure 5

(a) Change in connectivity profile of left- and right-sided potential targets identified based on pre-treatment and post-treatment scans. Group mean sgACC seed map connectivity remained relatively stable for RSNM targets and structural targets but was more unstable for the potential sgACC-derived targets. Each symbol represents 1 target; there were 2 targets per subject (right and left) × 13 subjects who underwent either active or sham rTMS treatment. (b) Spatial change in target coordinates between pre-treatment and post-treatment scans. After a course of RSNM-targeted treatment, the location of the potential sgACC-derived target sites changed significantly more than the location of RSNM-based target sites (p < 0.0001, Wilcoxon matched-pairs signed-rank test). (c) Treatment-induced change in connectivity within and between a priori ROIs. Active treatment was associated with connectivity changes within and between stimulation sites, sgACC, DAN, and DMN. Magnitude of change is quantified using Cohen’s d (adapted with permission from Siddiqi et al., J Neurotrauma 2019).

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