Table 3 (A) EC50, CC50, and SI index of 3 compounds of interest in MRC5 cells infected with HCoV-229E or HCoV-OC43.

From: Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

HCoV strain

Compound

EC50 (μM)

CC50 (μM)

SI index

HCoV-229E

Tanespimycin

0.0036

0.182

101

Bortezomib

0.2518

0.5364

2

Homoharringtonine

0.05106

0.2046

4

HCoV-OC43

Tanespimycin

0.0019

0.2528

133

Bortezomib

0.666

0.5914

 < 1

Homoharringtonine

0.1261

0.1670

1

  1. Tanespimycin and homoharringtonine exhibited anti-HCoV-229E with tanespimycin’s EC50 101 times lower than its CC50 and homoharringtonine 4 times lower. Tanespimycin was also effective against anti-HCoV-OC43 with an EC50 133 times lower than its CC50. Bortezomib exhibited no anti-viral activity against either strain.
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