Table 4 Selective pathways identified using top genes predicted by Auransa engine to be reversed by anti-viral compounds based on STRING DB analysis.

From: Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

Compounds

Pathway name

Source

Strength

FDR

Bortezomib

Canonical NF-kB pathways, and NF-kappa-B/Dorsal

STRING

1.81

0.00055

G2/M DNA replication checkpoint

REACTOME

1.99

0.0267

I-kappaB/NF-kappaB complex

GO-CC

1.99

0.0018

Homoharringtonine

I-kappaB/NF-kappaB complex

GO-CC

1.92

0.0013

Canonical NF-kB pathways, and NF-kappa-B/Dorsal

STRING

1.81

0.00082

Negative regulation of reactive oxygen species metabolic process

GO-BP

1.23

0.0105

Tanespimycin

Chaperone-mediated protein transport

GO-BP

1.73

0.0071

Cholesterol biosynthesis

UniProt

1.47

0.0137

Steroid biosynthesis

UniProt

1.65

0.00114

  1. A clear NFkB signature was likely the driver for predicting bortezomib and homoharringtonine as anti-viral compounds in host cells. In contrast, we hypothesize that tanespimycin targets the metabolism and protein folding/synthesis part of viral biology.
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