Table 2 Prevalence and gene frequency of thalassemia found among 371 subjects inhabiting at the border region of Thailand, Lao PDR and Cambodia (95% confidence interval in parentheses).
Type of Thalassemia | Kantharalak (n = 36, total 72 alleles) | Nam Khun (n = 109, total 218 alleles) | Nam Yuen (n = 98, total 196 alleles) | Na Chaluai (n = 128, total 256 alleles) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | Prevalence | Gene frequency | n | Prevalence | Gene frequency | n | Prevalence | Gene frequency | n | Prevalence | Gene frequency | |
− α3.7a | 12 | 33.3 | 0.167 | 36 | 33.3 | 0.165c | 46 | 46.9 | 0.235c, d | 37 | 28.9 | 0.145d |
(22.2–44.4) | (0.079–0.255) | (26.7–39.4) | (0.115–0.215) | (39.8–54.1) | (0.174–0.295) | (23.2–34.6) | (0.101–0.188) | |||||
− α4.2 | 1 | 2.8 | 0.014 | 2 | 1.8 | 0.009 | 0 | 0 | 0 | 2 | 1.1 | 0.008 |
(− 1.1–6.7) | (− 0.014–0.041) | (0–3.7) | (− 0.004–0.222) | (0–3.1) | (− 0.003–0.019) | |||||||
αCS | 4 | 11.1 | 0.056 | 19 | 17.4 | 0.087 | 18 | 18.4 | 0.092 | 16 | 12.5 | 0.063 |
(3.7–18.5) | (0.002–0.110) | (12.3–22.6) | (0.049–0.125) | (12.8–23.9) | (0.051–0.133) | (8.4–16.6) | (0.032–0.093) | |||||
αPS | 1 | 2.8 | 0.014 | 1 | 0.9 | 0.005 | 3 | 3.1 | 0.015 | 1 | 0.8 | 0.004 |
(− 1.1–6.7) | (− 0.014–0.041) | (− 0.4–2.2) | (− 0.005–0.014) | (0.6–5.5) | (− 0.002–0.033) | (− 0.3–1.9) | (− 0.004–0.012) | |||||
α0-thalassemia | 2 | 5.6 | 0.028 | 3 | 2.8 | 0.014 | 3 | 3.1 | 0.015 | 5 | 4.7 | 0.023 |
(0.2–11.0) | (− 0.011–0.067) | (0.5–5.0) | (− 0.002–0.030) | (0.6–5.5) | (− 0.002–0.033) | (2.0–7.3) | (0.005–0.042) | |||||
Hb Ea | 16 | 44.4 | 0.222 | 51 | 46.8 | 0.234 | 52 | 53.1 | 0.265 | 58 | 45.3 | 0.227 |
(32.7–56.2) | (0.124–0.320) | (40.0–53.5) | (0.177–0.291) | (45.9–60.2) | (0.202–0.328) | (39.1–51.5) | (0.174–0.279) | |||||
β-thalassemiab | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0.005 | 2 | 1.1 | 0.008 |
(− 0.4–2.5) | (− 0.005–0.015) | (0–3.1) | (− 0.003–0.019) | |||||||||