Table 2 Prevalence and gene frequency of thalassemia found among 371 subjects inhabiting at the border region of Thailand, Lao PDR and Cambodia (95% confidence interval in parentheses).

From: Anemia, iron deficiency, and thalassemia among the Thai population inhabiting at the Thailand-Lao PDR-Cambodia triangle

Type of Thalassemia

Kantharalak (n = 36, total 72 alleles)

Nam Khun (n = 109, total 218 alleles)

Nam Yuen (n = 98, total 196 alleles)

Na Chaluai (n = 128, total 256 alleles)

n

Prevalence

Gene frequency

n

Prevalence

Gene frequency

n

Prevalence

Gene frequency

n

Prevalence

Gene frequency

− α3.7a

12

33.3

0.167

36

33.3

0.165c

46

46.9

0.235c, d

37

28.9

0.145d

(22.2–44.4)

(0.079–0.255)

 

(26.7–39.4)

(0.115–0.215)

 

(39.8–54.1)

(0.174–0.295)

(23.2–34.6)

(0.101–0.188)

− α4.2

1

2.8

0.014

2

1.8

0.009

0

0

0

2

1.1

0.008

(− 1.1–6.7)

(− 0.014–0.041)

 

(0–3.7)

(− 0.004–0.222)

   

(0–3.1)

(− 0.003–0.019)

αCS

4

11.1

0.056

19

17.4

0.087

18

18.4

0.092

16

12.5

0.063

(3.7–18.5)

(0.002–0.110)

 

(12.3–22.6)

(0.049–0.125)

 

(12.8–23.9)

(0.051–0.133)

(8.4–16.6)

(0.032–0.093)

αPS

1

2.8

0.014

1

0.9

0.005

3

3.1

0.015

1

0.8

0.004

(− 1.1–6.7)

(− 0.014–0.041)

 

(− 0.4–2.2)

(− 0.005–0.014)

 

(0.6–5.5)

(− 0.002–0.033)

(− 0.3–1.9)

(− 0.004–0.012)

α0-thalassemia

2

5.6

0.028

3

2.8

0.014

3

3.1

0.015

5

4.7

0.023

(0.2–11.0)

(− 0.011–0.067)

 

(0.5–5.0)

(− 0.002–0.030)

 

(0.6–5.5)

(− 0.002–0.033)

(2.0–7.3)

(0.005–0.042)

Hb Ea

16

44.4

0.222

51

46.8

0.234

52

53.1

0.265

58

45.3

0.227

(32.7–56.2)

(0.124–0.320)

 

(40.0–53.5)

(0.177–0.291)

 

(45.9–60.2)

(0.202–0.328)

(39.1–51.5)

(0.174–0.279)

β-thalassemiab

0

0

0

0

0

0

1

1

0.005

2

1.1

0.008

(− 0.4–2.5)

(− 0.005–0.015)

(0–3.1)

(− 0.003–0.019)

  1. The overall prevalence of α+-thalassemia (− α3.7, −  α4.2, αCSα, αPSα): 199/371 = 53.6% (95%CI: 50.0–57.3), α0-thalassemia: 13/371 = 3.5% (95%CI: 2.2–4.9), Hb E: 177/371 = 47.7% (95%CI: 40.0–51.4), and β-thalassemia: 3/371 = 0.8% 95%CI: (0.2–1.5).
  2. a Including individuals with heterozygous and homozygous states.
  3. b Including two individuals with − 28 (A > G) (HBB: c. − 78A > G) and one individual with 3.4 kb deletion (NC_000011.10: g.5224302-5227791del13490bp).
  4. c Significant difference between Nan Khun and Nam Yuen (P value; 0.041).
  5. d Significant difference between Nam Yuen and Na Chaluai (P value; 0.005).