Figure 5 | Scientific Reports

Figure 5

From: Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

Figure 5

Genes downregulated in AD and upregulated with exercise composite. The 171 genes downregulated with AD and reversed by the exercise composite are plotted in STRING15. Lines between genes indicates connections and width of line reflects strength of evidence. Enrichment was found for: nervous system development (purple); KEGG AD pathway (red); cytoskeleton (blue); synapse (light blue); mitochondrion (green); cytoskeleton (light yellow); and interferon-stimulated related (yellow). Upper right shows RRHO heat map111 comparing exercise composite (Y axis) and AD portrait (X axis). Arrow highlights reversal of downregulated genes in AD by exercise.

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