Figure 6 | Scientific Reports

Figure 6

From: Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

Figure 6

AD dysregulated gene expression reversed by fluoxetine composite. Genes with the highest levels of protein–protein interaction (determined via STRING15) from the 271 AD genes reversed by fluoxetine composite are plotted in Cytoscape109. Increased size of font for gene symbol reflects higher number of connections between genes. BDNF, SYN1, GAD2, and VAMP2 were among the genes with the most connections. Interactions are highlighted by lines. AD upregulated genes downregulated by fluoxetine are shown in red and AD downregulated genes upregulated by fluoxetine are shown in blue. Upper right shows RRHO heat map111 comparing fluoxetine composite (Y axis) and AD portrait (X axis). Arrow highlights reversal of downregulated genes in AD by fluoxetine.

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