Figure 2

Isolated sEV-enriched fractions from participants’ plasma (a–c) TEM images showing that sEVs of three groups are oval or bowl-shaped capsules without a nucleus. d. The Western blot analysis of sEVs, markers CD9, CD63and TSG101were all detected in the sEV-enriched fractions isolated from plasma, and Calnexin, a negative marker of sEVs was absent in our isolated sEVs-enriched fraction samples. (e–g) NTA showed that the diameter and concentration of EVs for three groups. CL, control cell lysate.