Table 2 Clinical characteristics of the pregnant women with mild and severe ICP and normal pregnant women.

From: Diagnostic and prognostic value of blood inflammation and biochemical indicators for intrahepatic cholestasis of pregnancy in Chinese pregnant women

Variables

Normal (N = 363)

Mild ICP (N = 262)

Severe ICP (N = 42)

p-value

Age (years)

30.04 ± 4.00

29.48 ± 4.29

30.31 ± 4.18

0.095

Gestational week

34.08 ± 2.89

34.18 ± 3.75*

33.10 ± 4.62#

0.030

ALT (U/L)

16.80 (13.00, 24.30)

33.60 (30.37, 38.35)*

33.85 (29.75, 58.85)*

 < 0.001

AST (U/L)

19.00 (16.10, 22.90)

43.20 (20.22, 82.12)*

44.05 (17.00, 104.20)*

 < 0.001

GGT (U/L)

13.60 (9.30, 21.20)

22.00(9.92, 38.55)*

16.15 (8.90, 49.92)*

 < 0.001

PA (g/L)

206.00 (191.10, 221.50)

184.35(146.20, 212.90)*

179.05 (149.40, 211.52)*

 < 0.001

TBIL (μmol/L)

5.70 (4.40, 7.50)

7.40 (5.40, 10.10)*

7.80 (5.55, 10.35)*

 < 0.001

DBIL (μmol/L)

2.00 (1.60, 2.40)

3.00 (2.00, 4.50)*

3.50 (2.30, 6.47)*

 < 0.001

TBA (mmol/L)

2.10 (1.80, 4.40)

17.75 (13.27, 24.90)*

52.00 (44.75, 80.95)*#

 < 0.001

WBC × 109/L

7.28 (6.22, 8.63)

8.02(6.67, 9.28)*

7.44 (6.64, 8.37)

 < 0.001

PLT × 109/L

166.00 (133.00, 206.00)

171.00 (137.75, 215.50)

178.00 (139.25, 211.75)

0.154

Neutrophils × 109/L

5.22 (4.33, 6.32)

5.87 (4.87, 7.08)*

5.26 (4.55, 6.23)

 < 0.001

Lymphocytes × 109/L

1.62 (1.42, 1.86)

1.36 (1.15, 1.59)*

1.41 (1.18, 1.62)*

 < 0.001

NLR

3.23 (2.74, 3.83)

4.08 (3.47, 5.45)*

4.05 (2.90, 5.22)*

 < 0.001

PLR

101.09 (80.19, 123.91)

125.75 (96.99, 161.50)*

128.49 (98.23, 170.28)*

 < 0.001

  1. ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl transferase; PA, prealbumin; TBIL, total bilirubin; DBIL, direct bilirubin; TBA, bile acid; WBC, white blood cell count; PLT, platelets; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.
  2. *, p < 0.05, mild ICP/severe ICP compared with normal pregnancy;#, p < 0.05, severe ICP compared with mild ICP.
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