Table 2 The results of efficacy and safety in meta-analysis.

HbA1c

Dulaglutide 0.75 mg

Dulaglutide 1.5 mg

4

4

2052

2052

5

67

− 0.20 [− 0.28, − 0.11]

− 0.49 [− 0.67, − 0.30]

< 0.0001

< 0.0001

FPG

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

4

2052

1701

89

83

0.17 [− 0.34, 0.69]

0.31 [-0.85, 0.24]

0.51

0.27

Body Weight

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

4

2052

1701

94

76

− 1.43 [− 2.38, − 0.48]

− 2.12 [− 2.71, − 1.53]

0.003

< 0.0001

Systolic blood pressure

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

3

1680

1331

52

30

0.75 [− 2.39, 3.90]

− 0.74 [− 2.88, 1.40]

0.64

0.50

Diastolic blood pressure

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

3

1680

1331

0

0

0.25 [− 0.74, 1.23]

− 0.19 [− 1.59, 1.22]

0.62

0.79

HbA1c ≤ 6.5%

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

1641

79

84

1.34 [1.05, 1.71]

1.67 [1.21, 2.31]

0.02

0.002

Adverse events

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

1641

19

80

1.09 [1.01, 1.18]

1.12 [0.94, 1.35]

0.02

0.21

Serious adverse events

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

1641

0

0

1.35 [0.77, 2.36]

2.03 [1.17, 3.53]

0.29

0.01

Hypoglycemic episodes

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

1641

90

89

0.35 [0.16, 0.75]

0.35 [0.18, 0.67]

0.007

0.002

Nasopharyngitis

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1270

851

0

0

1.09 [0.74, 1.61]

1.19 [0.69, 2.04]

0.67

0.53

Decreased appetite

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

11,641

84

0

9.66 [2.18, 42.82]

21.56 [6.79, 68.50]

0.16

< 0.0001

Diarrhoea

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

3

2052

1641

0

0

2.63 [1.78, 3.88]

5.16 [3.46, 7.69]

< 0.0001

< 0.0001

Nausea

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

4

2052

1701

73

83

3.31 [0.92, 11.91]

7.20 [1.44, 36.09]

0.07

0.02

Abdominal distension

dulaglutide 0.75 mg

dulaglutide 1.5 mg

4

4

2052

1641

73

50

2.11 [0.52, 8.62]

6.80 [3.51, 13.16]

0.30

< 0.0001

Renal and urinary disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

0

0

1.01 [0.59, 1.70]

1.14 [0.63, 2.07]

0.98

0.66

Psychiatric disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

0

0

0.39 [0.13, 1.15]

1.15 [0.42, 3.13]

0.09

0.79

Eye disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

45

71

0.65 [0.31, 1.37]

0.81 [0.35, 1.91]

0.26

0.63

Cardiac disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

0

88

1.36 [0.76, 2.43]

0.75 [0.07, 8.32]

0.29

0.81

Endocrine disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

0

0

1.73 [0.37, 8.02

2.17 [0.49, 9.59]

0.48

0.31

Nervous system disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

0

0

1.04 [0.70, 1.53]

1.32 [0.82, 2.13]

0.86

0.26

Reproductive system disorders

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

20

0

4.06 [1.29, 12.80]

4.97 [0.58, 42.35]

0.02

0.14

Neoplasms

dulaglutide 0.75 mg

dulaglutide 1.5 mg

3

2

1289

876

59

0

0.97 [0.07, 13.99]

5.93 [0.71, 49.31]

0.98

0.26