Table 3 Summary of blood chemistry and biomarkers of inflammation.

From: Suppressed renoprotective purines in COVID-19 patients with acute kidney injury

 

No AKI

AKI

P-value

Sample size

23

21 (15a)

 

Blood urea nitrogen (mg/dL)

18.0 [12.5, 28.0]

66.0 [40.0, 100.0]

 < 0.01

Creatinine (mg/dL)

0.7 [0.6, 0.8]

2.5 [1.7, 3.3]

 < 0.01

White blood cell count (1000/µL)

9.7 [5.7, 12.8]

7.6 [6.1, 15.1]

0.99

Hemoglobin (g/dL)

12.9 [12.1, 14.2]

11.1 [9.4, 13.4]

 < 0.01

Platelets (1000/µL)

207.0 [161.0, 270.0]

163.0 [142.0, 202.0]

0.21

CO2 (mmol/L)

28.0 [24.0, 30.0]

23.0 [21.0, 27.0]

 < 0.05

Angiopoietin-2 (pg/mL)

5490.8 [2173.8, 15,011.9]

28,035.4 [3193.4, 41,064.9]

 < 0.05

Interleukin-8 (pg/mL)

11.2 [7.3, 20.5]

26.2 [18.3, 32.2]

 < 0.05

Interleukin-6 (pg/mL)

21.7 [6.9, 37.8]

82.6 [13.2, 114.8]

0.16

Procalcitonin (pg/mL)

102.3 [67.9, 161.5]

1039.5 [289.5, 2547.2]

 < 0.01

ST2 (pg/mL)

117,938.8 [61255.1, 164,618.7]

258,805.9 [188349.4, 433,301.3]

 < 0.01

Fractalkine (pg/mL)

187.2 [185.1, 976.9]

3264.7 [2024.9, 5311.8]

 < 0.01

Interleukin-10 (pg/mL)

0.7 [0.6, 4.4]

0.6 [0.6, 9.9]

0.58

Pentraxin-3 (pg/mL)

6338.2 [2024.9, 11,203.5]

19,529.0 [11424.0, 25,708.1]

 < 0.01

RAGE (pg/mL)

12,837.2 [2567.6, 33,369.6]

66,377.2 [7225.7, 124,459.9]

 < 0.05

TNFR-1 (pg/mL)

2409.6 [1792.9, 3598.6]

9297.0 [6966.2, 17,229.2]

 < 0.01

  1. aSample size for plasma biomarkers using Luminex analysis was 15. Values are median and interquartile range.