Figure 1 | Scientific Reports

Figure 1

From: Establishment of a novel mouse model of adenomyosis suitable for longitudinal and quantitative analysis and perinatal outcome studies

Figure 1

(A) A schema showing the punctures of the uterine horn. The entire uterine wall of one horn was mechanically punctured at a frequency of 100 times/1 cm. The puncture was crossed the whole uterine wall thickness. (B) A macroscopic finding of the uterus (D14 and D65). At D14, the adenomyosis horn was slightly shorter than the control horn, and the difference became more pronounced in D65. (C) A representative microscopic image of the control horn (D65, × 100). Hematoxylin and eosin staining (HE) shows the normal uterine architecture; cytokeratin 8 (CK8) shows eutopic endometrium and alpha smooth muscle actin (α SMA) shows smooth muscle architecture. (D) A representative microscopic image of the adenomyosis horn (D65, upper figures; ×100) (lower figures; ×400). Hematoxylin and eosin staining (HE) shows the uterine structure with an adenomyosis lesion (black box); cytokeratin 8 (CK8) shows eutopic endometrial epithelium and epithelium of the lesion (marked with black box), alpha smooth muscle actin (α SMA) shows smooth muscle structure that encircles adenomyosis lesion (marked with black box).

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