Figure 5 | Scientific Reports

Figure 5

From: A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation

Figure 5

Ammonia-related metabolites in the cerebrospinal fluid (CSF) of C57Bl/6j mice. (A–C) Relative CSF levels of (A) glutamine, glutamate and (C) osmolytes taurine and creatine in sham controls (n = 8) and BDL (n = 6/timepoint) animals at different timepoints. (B) Spearman correlation between CSF glutamine and plasma ammonia. Spearman correlation coefficient (r) and corresponding p-value are shown. Values are represented as mean ± SEM. *p < 0.05, **p < 0.01. BDL bile duct ligation, CSF cerebrospinal fluid.

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