Table 2 Course of renal function.

From: Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients

Ā 

No AKI (n = 19) (median ± IQR) or n (%)

AKI (n = 17) (median ± IQR) or n (%)

Baseline creatinine (μmol/L)

77 (62–102)

96 (84–132)

Baseline urea (mmol/L)

6 (5.3–8.4)

7.5 (6–10.0)

Baseline eGFR (ml/min/1.73m2)

90.7 (53.6–103.9)

68.4 (46.1–80.3)

CKD class: 1 (> 90)

10 (53%)

3 (18%)

CKD class: 2 (60–90)

4 (21%)

7 (41%)

CKD class: 3a (45–60)

1 (5%)

1 (6%)

CKD class: 3b (30–45)

0 (0%)

0 (0%)

CKD class: 4 (15–30)

3 (16%)

3 (18%)

CKD class: 5 (< 15)

1 (5%)

3 (18%)

Creatinine upon admission (μmol/L)

81 (65–105)

160 (104–222)**

eGFR upon admission (ml/min/1.73Ā m2)

80.9 (49.5–95.3)

40.3 (29.3–53.6)**

Urea/creatinine ratio at admission

90.2 (72.7–108.9)

76.4 (53.8–102.6)

Urea upon admission (mmol/L)

7.4 (5.5–10.3)

11.7 (8.9–16.5)*

Maximum creatinine < 48Ā h (μmol/L)

87 (66–105)

176 (118–222)**

Creatinine at discharge (μmol/L)

65 (57–90)

103 (77–134)

eGFR at discharge (ml/min/1.73m2)

88.3 (59.1–127.5)

69.6 (46.1–98.4)

Urea at discharge (mmol/L)

5.3 (3.7–8.6)

7.6 (6.8–9.4)

AKI at discharge

0 (0%)

1 (6%)

Creatinine after discharge (μmol/L)

65 (57–90)

103 (77–134)

eGFR after discharge (ml/min/1.73Ā m2)

88.3 (59.1–127.5)

69.6 (46.1–98.4)

  1. Although no changes in baseline renal function existed between patients with and without AKI, the serum creatinine level, eGFR upon admission, as well as the maximum serum creatinine reached during the first 48Ā h after hospitalization are different between groups. AKI acute kidney injury, CKD chronic kidney disease, eGFR estimated glomerular filtration rate, IQR interquartile range, */**means p < 0.05/0.01.