Table 3 Relative plasma levels of proteins extracted by principal component analysis.

From: Plasma proteomic characterization of the development of acute kidney injury in early sepsis patients

Symbol

Uniprot ID

Full name

Correlation PCA

FC AKI vs. no AKI

p-value

Adj. p-value

ADGRG1

Q9Y653

Adhesion G-protein coupled receptor G1

PC1

1.48

0.156

0.285

ATP6AP2

O75787

Renin receptor

PC2

1.06

1.000

0.982

BAMBI

Q13145

BMP and activin membrane-bound inhibitor homolog

PC2

1.45

0.021

0.093

BANK1

Q8NDB2

B-cell scaffold protein with ankyrin repeats

PC1

1.26

0.433

0.547

BID

P55957

BH3-interacting domain death agonist

PC2

0.82

0.778

0.809

BTC

P35070

Probetacellulin

PC1

1.18

0.146

0.298

CA12

O43570

Carbonic anhydrase 12

PC1, PC2

1.52

0.007

0.042

CA14

Q9ULX7

Carbonic anhydrase 14

PC2

1.76

0.049

0.137

CALCA

P06881

Calcitonin gene-related peptide 1

PC1

2.36

0.005

0.034

CALR

P27797

Calreticulin

PC1, PC2

1.36

0.002

0.022

CLEC1A

Q8NC01

C-type lectin domain family 1 member A

PC1, PC2

1.84

0.004

0.031

DSG4

Q86SJ6

Desmoglein-4

PC2

1.37

0.471

0.567

EGFL7

Q9UHF1

Epidermal growth factor-like protein 7

PC1

1.26

0.030

0.106

ENAH

Q8N8S7

Protein enabled homolog

PC1

1.25

0.219

0.352

ENTPD6

O75354

Ectonucleoside triphosphate diphosphohydrolase 6

PC1

1.25

0.300

0.454

FABP9

Q0Z7S8

Fatty acid-binding protein 9

PC2

1.27

0.093

0.197

FES

P07332

Tyrosine-protein kinase Fes/Fps

PC1, PC2

1.07

0.754

0.816

FGR

P09769

Tyrosine-protein kinase Fgr

PC1

1.08

0.639

0.736

FOSB

P53539

Protein fosB

PC1

1.22

0.076

0.168

FOXO1

Q12778

Forkhead box protein O1

PC1, PC2

1.08

0.379

0.515

INPPL1

O15357

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

PC1

1.21

0.300

0.442

KIM1

Q96D42

Kidney Injury Molecule 1

PC1

2.60

ā€‰<ā€‰0.001

0.008

LAT2

Q9GZY6

Linker for activation of T-cells family member 2

PC1

1.53

0.066

0.175

LTA4H

P09960

Leukotriene A-4 hydrolase

PC2

0.99

0.802

0.818

MAEA

Q7L5Y9

E3 ubiquitin-protein transferase MAEA

PC1

2.66

0.186

0.329

MAP4K5

Q9Y4K4

Mitogen-activated protein kinase kinase kinase kinase 5

PC1

0.68

0.285

0.444

MVK

Q03426

Mevalonate kinase

PC1, PC2

1.76

0.186

0.318

NBN

O60934

Nibrin

PC1

1.27

0.379

0.502

NOS3

P29474

Nitric oxide synthase, endothelial

PC1

1.77

0.038

0.119

NPPC

P23582

C-type natriuretic peptide

PC1

4.67

ā€‰<ā€‰0.001

0.010

NUB1

Q9Y5A7

NEDD8 ultimate buster 1

PC1

1.16

0.471

0.555

NUCB2

P80303

Nucleobindin-2

PC2

1.76

0.002

0.019

PDGFC

Q9NRA1

Platelet-derived growth factor C

PC1

1.30

0.330

0.460

PGF

P43088

Prostaglandin F2-alpha receptor

PC2

1.81

ā€‰<ā€‰0.001

0.015

PON2

Q15165

Serum paraoxonase/arylesterase 2

PC2

0.98

0.802

0.802

PRKAB1

Q9Y478

5ā€²-AMP-activated protein kinase subunit beta-1

PC1

1.33

0.012

0.058

PRKRA

O75569

IFN-inducible dsRNA-dependent protein kinase activator A

PC1

1.02

0.754

0.799

PTK7

Q13308

Inactive tyrosine-protein kinase 7

PC2

1.67

0.008

0.043

PTPRJ

Q12913

Receptor-type tyrosine-protein phosphatase Ī²

PC1

1.06

0.300

0.430

PVALB

P20472

Parvalbumin alpha

PC1

2.12

0.186

0.308

PXN

P49023

Paxillin

PC1

1.07

0.379

0.490

RARRES1

P49788

Retinoic acid receptor responder protein 1

PC1

1.33

0.023

0.087

RASSF2

P50749

Ras association domain-containing protein 2

PC1, PC2

0.96

0.684

0.771

RRM2B

Q7LG56

Ribonucleoside-diphosphate reductase subunit M2 B

PC1

2.13

0.021

0.086

SERPINA9

Q86WD7

Serpin A9

PC2

1.10

0.433

0.534

ST3GAL1

Q11201

CMP-N-acetylneuraminate-Ī²-galactosamide-Ī±-2,3-sialyltransferase 1

PC2

1.06

0.731

0.807

STX8

Q9UNK0

Syntaxin-8

PC1

1.53

0.033

0.110

TIGAR

Q9NQ88

Fructose-2,6-bisphosphatase

PC1

1.72

0.045

0.133

TMPRSS15

P98073

Enteropeptidase

PC2

1.67

0.146

0.287

TNNI3

P19429

Troponin I, cardiac muscle

PC1

3.22

0.071

0.164

TOP2B

Q02880

DNA topoisomerase 2-Ī²

PC1

1.35

0.146

0.277

VEGFC

P49767

Vascular endothelial growth factor C

PC2

2.61

0.066

0.167

YES1

P07947

Tyrosine-protein kinase Yes

PC1

1.39

0.066

0.159

  1. Principal component analysis revealed 38 proteins to be correlated with PC1 and 22 proteins to be associated with PC2, of which nine proteins are different between AKI as compared to non-AKI controls (bold). AKI acute kidney injury, FC fold change.
Back to article page