Table 5 Pathway analysis by Enrichr/NCI Nature 2016.

Pathway name	p-value	Adjusted p-value	Odds ratio	Combined score
Signalling events mediated by VEGFR1 and VEGFR2	< 0.001	< 0.001	36.71	526.02
Angiopoietin receptor Tie2-mediated signalling	< 0.001	< 0.001	41.13	500.00
PDGF receptor signalling network	0.014	0.049	84.88	360.44
Class I PI3K signalling events	< 0.001	0.003	29.49	250.03
Alpha9 beta1 integrin signalling events	0.002	0.015	37.67	241.75
Glypican 1 network	0.002	0.015	34.66	217.05
Thromboxane A2 receptor signalling	< 0.001	0.004	25.03	200.74
Ephrin B reverse signalling	0.002	0.015	30.94	187.27
Regulation of p38-alpha and p38-beta	0.002	0.015	30.94	187.27
CXCR4-mediated signalling events	< 0.001	0.002	18.80	173.82
Alpha-synuclein signalling	0.003	0.016	28.87	171.07
EPHA forward signalling	0.003	0.016	27.07	157.11
Signalling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	< 0.001	0.009	17.91	126.87
amb2 Integrin signalling	0.004	0.019	22.78	124.96
Signalling events mediated by PTP1B	0.007	0.030	17.31	86.05
Signalling events mediated by focal adhesion kinase	0.009	0.033	15.45	73.54
Fc-epsilon receptor I signalling in mast cells	0.009	0.033	15.45	73.54
PDGFR-beta signalling pathway	0.003	0.018	10.57	59.53
CDC42 signalling events	0.012	0.044	12.71	55.94

Proteins that correlated with PC1 and/or PC2 and which were positive differentially expressed proteins among patients with sepsis-AKI as compared to patients without AKI. The proteins were used to identify pathways affected by sepsis-AKI, only pathways with an adjusted p-value < 0.05 are shown.

Quick links

Search