Table 1 Neuroprotective activity of metabolites against H2O2 toxicity. Data are presented as means ± S.D (n = 3). *p < 0.05, **p < 0.05, ***p < 0.001, ****p < 0.0001 significant difference from H2O2-treated cells.
From: Neuroprotective metabolites via fungal biotransformation of a novel sapogenin, cyclocephagenol
Metabolite | Concentration | Cell viability (%) | Metabolite | Concentration | Cell viability (%) |
|---|---|---|---|---|---|
2 | 1 nM | 56.2 ± 1.8**** | 12 | 1 nM | 36.2 ± 1.9 |
10 nM | 61.4 ± 3.7**** | 10 nM | 46.2 ± 1.8* | ||
100 nM | 61.1 ± 0.7**** | 100 nM | 49.0 ± 6.2** | ||
1000 nM | 58.1 ± 5.9**** | 1000 nM | 42.4 ± 2.0 | ||
3 | 1 nM | 46.8 ± 6.0 | 13 | 1 nM | 51.5 ± 7.9 |
10 nM | 46.7 ± 2.1 | 10 nM | 56.4 ± 3.0* | ||
100 nM | 50.9 ± 0.2** | 100 nM | 58.1 ± 12.1* | ||
1000 nM | 65.9 ± 2.3**** | 1000 nM | 66.4 ± 9.3** | ||
4 | 1 nM | 34.1 ± 0.4 | 14 | 1 nM | 60.8 ± 4.4**** |
10 nM | 59.7 ± 3.5**** | 10 nM | 56.5 ± 4.2**** | ||
100 nM | 56.3 ± 3.3**** | 100 nM | 39.9 ± 2.7 | ||
1000 nM | 53.6 ± 5.9**** | 1000 nM | 34.1 ± 1.3 | ||
5 | 1 nM | 26.9 ± 2.5 | 15 | 1 nM | 37.0 ± 3.0 |
10 nM | 25.1 ± 3.6 | 10 nM | 41.2 ± 2.6 | ||
100 nM | 43.8 ± 1.3 | 100 nM | 43.5 ± 5.3* | ||
1000 nM | 42.5 ± 5.7 | 1000 nM | 37.0 ± 0.5 | ||
6 | 1 nM | 45.7 ± 2.4 | 16 | 1 nM | 42.0 ± 2.3 |
10 nM | 46.0 ± 5.9 | 10 nM | 46.5 ± 7.2 | ||
100 nM | 54.8 ± 5.8*** | 100 nM | 42.7 ± 3.1 | ||
1000 nM | 52.1 ± 1.3* | 1000 nM | 41.4 ± 6.6 | ||
7 | 1 nM | 42.6 ± 3.9 | 17 | 1 nM | 41.9 ± 1.4 |
10 nM | 45.9 ± 5.6 | 10 nM | 42.7 ± 2.3 | ||
100 nM | 55.6 ± 13.3* | 100 nM | 62.8 ± 7.9*** | ||
1000 nM | 49.0 ± 3.9 | 1000 nM | 72.5 ± 13.3**** | ||
8 | 1 nM | 36.6 ± 11.0 | 18 | 1 nM | 44.0 ± 0.7 |
10 nM | 40.3 ± 1.5 | 10 nM | 42.0 ± 0.8 | ||
100 nM | 36.6 ± 2.7 | 100 nM | 44.4 ± 0.9 | ||
1000 nM | 40.2 ± 12.9 | 1000 nM | 38.1 ± 4.8 | ||
9 | 1 nM | 44.2 ± 2.3 | 19 | 1 nM | 38.0 ± 1.9 |
10 nM | 46.2 ± 3.2 | 10 nM | 40.5 ± 7.1 | ||
100 nM | 51.4 ± 4.8* | 100 nM | 39.9 ± 4.7 | ||
1000 nM | 70.5 ± 0.8**** | 1000 nM | 49.1 ± 3.6 | ||
10 | 1 nM | 51.1 ± 8.5* | 20 | 1 nM | 56.8 ± 1.9** |
10 nM | 58.5 ± 3.4*** | 10 nM | 58.3 ± 6.3** | ||
100 nM | 74.7 ± 3.3**** | 100 nM | 70.6 ± 6.9**** | ||
1000 nM | 68.1 ± 4.8**** | 1000 nM | 64.8 ± 6.0**** | ||
11 | 1 nM | 38.2 ± 0.7 | 21 | 1 nM | 47.0 ± 1.6** |
10 nM | 43.9 ± 6.2 | 10 nM | 44.7 ± 2.4* | ||
100 nM | 46.9 ± 9.5 | 100 nM | 38.7 ± 3.1 | ||
1000 nM | 54.3 ± 3.7** | 1000 nM | 35.7 ± 1.4 | ||
H2O2 | 70 µM | 37.9 ± 2.0 | |||
