Figure 1

Schema of the training protocol and measurements The participants were randomly assigned to either group: 8-week aerobic cycle training with (BFR group) or without (CON group) blood flow restriction (BFR) and trained for 30 min, 3 days a week for 8 weeks. Cycle training did not occur during the fifth week, and mid-measurements were collected. In the BFR group, cuffs were worn on the upper thighs, and pressure was applied for 5 min every 10 min of exercise. Peak oxygen uptake (\( {\dot{\text{V}}}{\text{O}} {{2{\text{peak}}}} \)), oxygen uptake (\( {\dot{\text{V}}}{\text{O}}_{2} \)) kinetic parameters during moderate-intensity constant-load exercise, maximal voluntary contraction (MVC) force in knee extensors, and cardio-ankle vascular index (CAVI) were assessed before (Pre) and after 4 (Mid) and 8 (Post) weeks training. In addition, blood from each participant was sampled in Pre and Post to evaluate markers of coagulation and fibrinolysis.