Figure 6
Anti-SARS-CoV-2 S total IgG underestimates neutralization potential evaluated using the SARS-CoV-2 pseudotyped VP-based assay. (A) SARS-CoV-2 S ELISA-based quantification of total IgG in COVID-19 convalescent sera, BNT162b2 vaccinated sera and pre-pandemic sera. (B) ID50 of all samples tested with SARS-CoV-2 S pseudoVP assay. Fully colored symbols indicate matched samples also tested in (A, C, D). (C) Correlation 1:20 sera neutralization potential vs. SARS-CoV-2 S IgG ratio. Purple: COVID-19 convalescent sera, orange: vaccinated sera, p < 0.001 (***) Black: pre-pandemic sera. (D) Comparison of COVID-19, BNT162b2 and pre-pandemic sera neutralization with pseudotyped VP-based assay and cPass SARS-CoV-2 ELISA.
