Figure 2

Correlation of TBA detected by cycling enzymatic assay and LC‒MS in all the participants. The green and red dots represent normal pregnant women and women with ICP, respectively (A). Pie charts show the percentage variation of BA individuals in TBA between NC (B) and ICP patients (C), (P: primary BAs, S: secondary BAs, G: glycine conjugated BAs, T: taurine conjugated BAs). T test of BA metabolism changes compared with the normal control (D). *P < 0.05; **P < 0.01; ****P < 0.0001.