Table 5 Molecular and fragment ions peaks in positive and negative ionization mode.

From: AQbD based green UPLC method to determine mycophenolate mofetil impurities and Identification of degradation products by QToF LCMS

S. no.

Name of the peak

Positive mode (m/z values)

Negative mode (m/z values)

Molecular ion peaks (Low collision energy)

Fragment ion peaks (High collision energy)

Molecular ion peaks (Low collision energy)

Fragment ion peaks (High collision energy)

1

RT 7.70

507.18359 [M + Na]+, 502.22833 [M + NH4]+

467.19241, 449.18087, 343.11522, 321.13318, 303.12380, 285.11280, 275.12820, 229.04785, 207.06568, 195.06490

483.18785 [M − H]–

341.10144, 319.11937, 301.10860, 287.09036, 275.12925, 269.08292, 207.06604, 191.03611

2

RT 7.89

507.18366 [M + Na]+, 502.22819 [M + NH4]+

467.19241, 449.18199, 343.11497, 321.13428, 303.12389, 285.11257, 275.12835, 229.04739, 207.06574, 195.06533

483.18781 [M − H]–

341.10124, 319.11929, 301.10784, 287.09376, 275.12922, 269.08347, 207.06505, 191.03552

3

RRT 8.05

507.18394 [M + Na]+, 502.22843 [M + NH4]+

467.19221, 449.18159, 343.11562, 321.13409, 303.12392, 285.11281, 275.12857, 229.04697, 207.06586, 195.06513

483.18779 [M − H]–

341.10100, 319.11952, 301.10903, 287.09215, 275.12946, 269.08354, 207.06445, 191.03569

4

Imp-H (Mycophenolic acid sorbitol ester)

507.18411 [M + Na]+, 502.22871 [M + NH4]+

467.19312, 449.18223, 343.11616, 321.13446, 303.12423, 285.11304, 275.12892, 229.04739, 207.06596, 195.06549

483.18737 [M − H]–

341.10092, 319.11932, 301.10788, 287.09276, 275.12914, 269.08243, 207.06515, 191.03538

5

Imp-C (MPA)

343.11636 [M + Na]+, 338.16098 [M + NH4]+, 321.13451 [M + H]+

303.12495, 275.12954, 229.04750, 207.06646, 195.06633, 159.04514

319.11855 [M − H]–

287.09244, 275.12891, 269.08172, 244.06643, 207.06590, 191.03523, 179.03514

6

Active drug (MPM)

456.20026 [M + Na]+, 434.21818 [M + H]+

347.15017, 303.12417, 285.11384, 207.06655, 195.06633, 159.04457, 114.08877

432.20233 [M − H]–

400.17589, 371.13593, 301.10867, 269.08167, 245.08152, 217.04763, 191.03482

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