Table 4 Dose-effect curve parameters of Allium sativum extract, silymarin standard extract and silibinin individually and their binary combinations with brequinar.

From: Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and in vitro approach

Drug

Dose-effect curve parameters

Dm

m

r

Allium sativum extract

202.972 (ug/ml)

1.26701

0.99998

Silymarin standard extract

133.538 (ug/ml)

1.56510

1.00000

Silibinin

122.127 (nM)

1.00184

0.99999

Brequinar

9.76713 (nM)

1.33376

0.99999

Allium sativum extract + Brequinar

141.25 (ug/ml)

1.107

0.99889

Silymarin standard extract + Brequinar

135.453 (ug/ml)

1.027

0.99999

Silibinin + Brequinar

127.135 (nM)

2.2

0.98999

  1. The boundaries Dm, m and r are the antilog of x-intercept, the slope and the linear correlation coefficient of the median-effect plot, respectively. CompuSyn was employed for automatic calculations.
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