Figure 2 | Scientific Reports

Figure 2

From: Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

Figure 2

Differential gene expression analysis revealed related changes in TNF-α and IL-6 treated eyes compared to VEGF. (a) Numbers of differentially expressed genes in each treatment compared to their respective controls (BH-adjusted p-value < 0.05). (b) Volcano plots indicating top differentially regulated genes in retina and eye cup tissue upon injection with AAV-VEGF, AAV-TNF-α, or AAV-IL-6. (c) Venn diagrams representing sets of differentially expressed genes overlapping between treatment groups. 820 genes were specifically regulated by AAV-VEGF. Large overlap between TNF-α and IL-6-induced differentially regulated genes in both retina and eye cup tissue. (d) Spearman correlation verified a strong correlation between TNF-α and IL-6-induced gene expression changes in both retina and eye cup tissue. Dendogram shows hierarchical clustering and therefore similarity of treatment induced fold-changes compared to their respective controls.

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