Table 2 Genotyped EGFR SNP information and association of variants with risk of glioma.

SNP	Allele	Coordinate	Position (AA change)	MAF		HWE P		Additive		P^corrc
SNP	Allele	Coordinate	Position (AA change)	Glioma (n = 324)	PCs (n = 480)	Glioma (n = 324)	PCs (n = 480)	OR (95%CI)	P	P^corrc
rs2252586^a	G>A	54,978,924	5'UTR	0.008	0.023	0.89	0.61	0.32 (0.12–0.86)	0.01	NS
rs2072454^b	C>T	55,214,348	Exon 4 (N158N)	0.384	0.325	0.68	0.59	1.34 (1.08–1.66)	0.008	NS
rs11506105^a	A>G	55,220,177	Intron	0.377	0.372	0.81	0.54	1.04 (0.84–1.30)	0.698	NS
rs2302536	G>A	55,224,338	Exon 9 (P373P)	0.005	0.005	0.93	0.91	0.79 (0.18–3.40)	0.75	NS
rs147732025	C>T	55,227,971	Exon 12 (L480L)	0.002	0.006	0.98	0.89	0.27 (0.03–2.26)	0.16	NS
rs142429250	G>A	55,229,247	Exon 13 (P518P)	0.006	0.003	0.91	0.95	2.12 (0.46–9.78)	0.33	NS
rs2227983	A>G	55,229,255	Exon 13 (R521K)	0.481	0.394	0.42	0.79	1.42 (1.16–1.74)	0.0007	0.009
rs1468727 ^a	T>C	55,230,105	Intron	0.479	0.436	0.49	0.85	1.18 (0.96–1.45)	0.12	NS
rs2227984	A>T	55,238,874	Exon 16 (T629T)	0.422	0.357	0.99	0.37	1.32 (1.07–1.62)	0.01	NS
rs1050171	G>A	55,249,063	Exon 20 (Q787Q)	0.179	0.115	0.92	0.75	1.68 (1.26–2.24)	0.0004	0.005
rs1140475	C>T	55,266,417	Exon 23 (T903T)	0.050	0.047	0.35	0.96	1.05 (0.65–1.70)	0.83	NS
rs2293347	G>A	55,268,916	Exon 25 (D994D)	0.319	0.359	0.09	0.55	0.82 (0.67–1.02)	0.07	NS
rs78244461	C>T	55,269,456	Exon 26 (A1048V)	0.005	0.002	0.93	0.96	2.00 (0.33–12.14)	0.45	NS

Logistic regression analysis under additive model was used for calculating ORs and corresponding P-values for SNPs controlling age and sex as covariates.
AA amino acid, MAF minor allele frequency, PC population control, HWE Hardy–Weinberg equilibrium, OR odds ratio, CI confidence interval, NS not significant.
Significant associations are shown in bold face.
The major allele of each variant was used as reference.
^aSNPs reported in previous study on glioma.
^bIn absolute LD with rs730437 (r² = 1 & D’ = 1) (SNiPA (https://snipa.helmholtz-muenchen.de/snipa3/)).
^cBonferroni-adjusted P-values by 13 SNP tests.

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