Figure 3

Hazard ratios (95% confidence interval) by groups of: (A) systolic blood pressure (SBP); and (B) diastolic blood pressure (DBP), and bladder cancer genetic score, including their multiplicative and additive interaction p-values, in relation to risk of urothelial cancer outcomes in the Malmö Diet and Cancer Study (MDCS; N _participants = 10,339; N _cases = 371). Hazard ratios were calculated by Cox regression with attained age as the underlying time scale, with adjustment for smoking, BMI, physical activity and level of education. The Relative excess risk for interaction (RERI) was calculated as RR₁₁-RR₁₀-RR₀₁ + 1, where: RR₀₀ (or 1, reference group) represented individuals with normal SBP/DBP (< 140/90) and lower 50% of the BC genetic risk; RR₁₀ represented those with high SBP/DBP (≥ 140/90) and lower 50% of BC genetic risk; RR₀₁ represented those with normal SBP and upper 50% of BC genetic risk; and RR₁₁ representing those with high SBP and upper 50% of BC genetic risk. The confidence intervals for RERI were obtained using the delta method, the p-value for additive interaction (p-value [add.]) was obtained from the RERI model. Multiplicative interaction was calculated using the likelihood ratio test (LR test). P-value (multi.) is the p-value for the multiplicative interaction obtained from the likelihood ratio test.