Figure 4
From: EZH2 regulates oncomiR-200c and EMT markers in esophageal squamous cell carcinomas
In our study demonstrated that Eectopic expression of EZH2 in ESCC lines upregulates Mir-200c and mesenchymal genes expression while down-regulates expression of epithelial gene. EZH2-overexpressing cell lines YM-1 and KYSE-30 overexpressed miR-200c nearly 2.07 and 3.81-folds compared to control cells, as well as an increase in ZEB2, Fibronectin, N-cadherin and Vimentin mRNA levels, and a decrease in the level of the epithelial gene expression (E-Cadherin and Occludin). The use of an asterisk (*) denotes statistical significance.
