Figure 8

An overview of the role of mir-200c in various cancers: E2F3 controls EZH2 expression at the transcriptional level in prostate cancer, MiR-200c can regulate E2F3 translation directly by targeting its mRNA 3′ UTR and cause a decrease in E2F3 level in the cell leading to a significant decline in EZH2 gene expression⁵². In line with this evidence, an association was detected between miR-200c overexpression and down regulation of E2F3 and BMI-1 genes in bladder cancer⁵³. miR-200c plays a tumor suppressor role in hepatocarcinoma, EZH2 can epigenetically silence miR-200c leading up-regulation of BMI-1 followed by an increase in proliferation and metastasis of the malignancy⁵⁵. Interestingly, the expression of the stem cell-associated genes EZH2 and Bmi1 was significantly reduced in breast cancer cells after miR-200c induction metastasis and tumor growth⁵⁶. miR-200c is increased in prostate, breast, bladder, and lung cancers. miR-200c reduces EZH2 and E2F3 genes that cause tumor development in prostate cancer. In bladder cancer, reducing E2F3 and BMI1 genes reasons metastasis and cancer proliferation. In breast cancer downregulating EZH2 and BMI1 genes, affects tumor growth and metastasis. In contrast, in hepatocellular cancer miR-200c knockdown increased EZH2 and BMI1 leading to tumorigenesis.