Table 3 Estimated latent class mixed model for CD8 (square root transformed) with one latent class.

From: Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models

Parameter

Estimate

SE

p-value

intercept (not estimated)

–

  

Sex (male vs. female)

0.4939

0.4250

0.2452

CCR5-delta32 polymorphism (WT/WT vs. WT/delta 32)

0.1021

0.5303

0.8474

Risk factor for HIV infection (sexual vs. IVDU)

− 0.3013

0.5426

0.5787

Anti-HCV (pos vs. neg)

− 0.6821

0.5168

0.1868

AIDS defining disease (yes vs. no)

− 0.0775

0.3714

0.8346

−168/PKR genotype (CT vs. CC)

0.8017

0.3860

0.0378

Age, years

− 0.0301

0.0275

0.2732

Duration of HIV infection

− 0.0040

0.0346

0.9091

Time

− 0.0077

0.0029

0.0073

Time: −168/PKR genotype (CT vs. CC)

0.0013

0.0035

0.7144

  1. The term “time: −168/PKR genotype” indicates the parameter for the interaction term, allowing to describe the progression of CD8 for each −168/PKR allelic variant.
  2. WT/WT wild type, anti-HCV hepatitis C virus antibodies, AIDS acquired immune deficiency syndrome, PKR protein kinase R.
  3. Significant coefficients are in bold.
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