Table 3 Expression level of p53, TNF-α, IL-6 and Presenillin-1 in the brain tissue of the negative control group and groups administered acrylamide or/and TiO₂NPs.

I

Negative control

(deionized water)

1.00 ± 0.00^a

1.00 ± 0.00^a

1.00 ± 0.00^a

1.00 ± 0.00^a

II

Acrylamide (3 mg/kg)

4.23 ± 0.28^b

2.71 ± 0.14^b

3.35 ± 0.11^b

2.32 ± 0.07^b

III

TiO₂-NPs (5 mg/kg)

2.12 ± 0.18^c

2.06 ± 0.15^c

2.36 ± 0.07^c

1.94 ± 0.16^c

IV

Acrylamide + TiO₂-NPs

4.75 ± 0.24^d

3.59 ± 0.17^d

5.26 ± 0.23^d

2.22 ± 0.10^b

One Way Analysis of Variance

F = 214.55

P < 0.001

F = 215.37

P < 0.001

F = 541.18 P < 0.001

F = 105.51 p < 0.001