Table 3 Correlation among the ∆FC between regions of interest before and after a cold pressor test and potential confounding factors according to the BDNF genotypes (n = 42).

From: Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study

BDNF Val/Val genotype (n = 30)

 

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

(10)

(11)

(1) ΔFC l-PFC—l-MC

1

          

(2) ΔFC l-PFC—r-FC

0.73**

1

         

(3) ΔFC l-PFC—r-MC

0.77**

0.73**

1

        

(4) ΔFC l-MC—r-PFC

0.91**

0.70**

0.73**

1

       

(5) ΔFC l-MC—r-MC

0.76**

0.45*

0.77**

0.78**

1

      

(6) ΔFC r-PFC—r-MC

0.69**

0.62**

0.92**

0.73**

0.71**

1

     

(7) CPM test score

 − 0.33

 − 0.25

 − 0.14

 − 0.38

 − 0.29

 − 0.20

1

    

(8) FIQ

 − 0.02

0.19

 − 0.03

0.01

 − 0.11

 − 0.01

 − 0.11

1

   

(9) ACR score

 − 0.07

 − 0.06

 − 0.13

 − 0.09

 − 0.25

0.02

0.04

0.19

1

  

(10) serum BDNF ng/ml

0.43*

0.34

0.36*

0.33

0.42*

0.17

 − 0.35

 − 0.08

 − 0.46*

1

 

(11) PCS

 − 0.11

 − 0.15

 − 0.10

 − 0.13

0.03

 − 0.19

0.35

0.4*

 − 0.01

 − 0.15

1

(12) BDI-II

0.28

0.21

0.13

0.27

0.25

0.08

0.15

0.45*

0.12

0.04

0.45*

BDNF Val/Mel genotype (n = 12)

 

(1)

(2)

(3)

(4)

(5)

(6)

(7)

(8)

(9)

(10)

(11)

(1) ΔFC l-PFC—l-MC

1

          

(2) ΔFC l-PFC—r-FC

0.57

1

         

(3) ΔFC l-PFC—r-MC

0.66*

0.38

1

        

(4) ΔFC l-MC—r-PFC

0.91**

0.77**

0.59*

1

       

(5) ΔFC l-MC—r-MC

0.71*

0.22

0.66*

0.57

1

      

(6) ΔFC r-PFC—r-MC

0.91**

0.62*

0.69*

0.9**

0.76**

1

     

(7) CPM test score

 − 0.4

 − 0.11

0.08

 − 0.55

 − 0.21

 − 0.48

1

    

(8) FIQ

0.16

0.24

0.2

0.36

0.35

0.28

 − 0.62

1

   

(9) ACR score

0.75**

0.49

0.51

0.82**

0.59*

0.79**

 − 0.71*

0.74**

1

  

(10) serum BDNF ng/ml

0.36

0.5

0.24

0.45

0.17

0.23

0.03

0.14

0.1

1

 

(11) PCS

0.21

0.15

0.29

0.33

0.3

0.26

 − 0.49

0.69*

0.4

0.47

1

(12) BDI-II

0.21

0.37

 − 0.09

0.36

0.06

0.31

 − 0.57

0.43

0.4

0.3

0.65*

  1. BDNF brain-derived neurotrophic factor. Val/Val Val66Val homozygous. Val/Met Val66Met heterozygous. ΔFC difference in functional connectivity. l- left. r- right. PFC prefrontal cortex. MC motor cortex. CPM conditioned pain modulation. FIQ Fibromyalgia Impact Questionnaire; ACR score American College of Rheumatology score for fibromyalgia diagnosis. PCS Pain Catastrophizing Scale. BDI-II Beck Depression Inventory II.
  2. *p < 0.05.
  3. **p < 0.01.
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