Table 4 MANCOVA analysis of the relationship between the ∆FC regions of interest before and after a cold pressor test according to the BDNF Val/Met genotype (n = 42).

From: Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study

Dependent variable

Type III sum of squares

df

Mean square

F

Sig.

Partial eta squared

Corrected model

ΔFC l-PFC—l-MC

0.847a

3

0.282

3.853

0.017

0.233

ΔFC l-PFC—r-PFC

0.740b

3

0.247

3.787

0.018

0.230

ΔFC l-PFC—r-MC

0.712c

3

0.237

3.575

0.023

0.220

ΔFC l-MC—r-PFC

0.906d

3

0.302

3.871

0.016

0.234

ΔFC l-MC—r-MC

0.676e

3

0.225

2.333

0.089

0.156

ΔFC r-PFC—r-MC

0.683f

3

0.228

2.464

0.077

0.163

Parameter

β

SE

t

Sig.

CI 95%

 

Dependent variable: ΔFC l-PFC—l-MC

 

Intercept

 − 0.622

0.304

 − 2.042

0.048

(− 1.23 to − 0.005)

 

BDNF Val/Val (n = 30)

 − 0.257

0.100

 − 2.586

0.014

(− 0.45 to − 0.06)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.025

0.012

1.995

0.053

(0.00 to 0.05)

 

Serum BDNF (ng/ml)

0.005

0.002

2.708

0.010

(0.001 to 0.01)

 

Dependent variable: ΔFC l-PFC—r-PFC

 

Intercept

 − 0.445

0.287

 − 1.550

0.129

(− 1.02 to 0.14)

 

BDNF Val/Val (n = 30)

 − 0.249

0.094

 − 2.656

0.012

(− 0.43 to − 0.06)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.017

0.012

1.451

0.155

(− 0.007 to 0.04)

 

Serum BDNF (ng/ml)

0.005

0.002

2.741

0.009

(0.001 to 0.09)

 

Dependent variable: ΔFC l-PFC—r-MC

 

Intercept

 − 0.442

0.290

 − 1.526

0.135

(− 1.03 to 0.14)

 

BDNF Val/Val (n = 30)

 − 0.226

0.095

 − 2.390

0.022

(− 0.42 to − 0.04)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.015

0.012

1.298

0.202

(− 0.009 to 0.04)

 

Serum BDNF (ng/ml)

0.005

0.002

2.829

0.007

(0.002 to 0.009)

 

Dependent variable: ΔFC l-MC—r-PFC

 

Intercept

 − 0.731

0.314

 − 2.327

0.025

(− 1.37 to − 0.09)

 

BDNF Val/Val (n = 30)

 − 0.260

0.103

 − 2.533

0.016

(− 0.47 to − 0.05)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.029

0.013

2.227

0.032

(0.003 to 0.06)

 

Serum BDNF level (ng/ml)

0.006

0.002

2.643

0.012

(0.001 to 0.01)

 

Dependent variable: ΔFC l-MC—r-MC

 

Intercept

 − 0.490

0.349

 − 1.404

0.169

(− 1.19 to 0.21)

 

BDNF Val/Val (n = 30)

 − 0.216

0.114

 − 1.893

0.066

(− 0.45 to 0.02)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.018

0.014

1.239

0.223

(− 0.011 to 0.05)

 

Serum BDNF (ng/ml)

0.005

0.002

2.293

0.027

(0.001 to − 0.01)

 

Dependent variable: ΔFC r-PFC r-MC

 

Intercept

 − 0.808

0.342

 − 2.364

0.023

(− 1.50 to − 0.12)

 

BDNF Val/Val (n = 30)

 − 0.183

0.112

 − 1.633

0.111

(− 0.40 to 0.04)

 

BDNF Val/Met (n = 12)

0Reference

     

ACR score

0.031

0.014

2.209

0.033

(0.003 to 0.06)

 

Serum BDNF (ng/ml)

0.005

0.002

2.006

0.052

(− 4.09 to 0.009)

 
  1. Df degrees of freedom. χ2 Wald Chi-Square. CI confidence interval. β regression coefficient. SE standard error. Sig. p-value. BDNF brain-derived neurotrophic factor. ACR American College of Rheumatology. ΔFC functional connectivity. Val/Val Val66Val homozygous. Val/Met Val66Met heterozygous. PFC prefrontal cortex. MC motor cortex. -l left. -r right. ACR score American College of Rheumatology score for fibromyalgia diagnosis. BDI-II Beck Depression Inventory II.
  2. aR Squared = 0.233 (Adjusted R Squared = 0.173).
  3. bR Squared = 0.230 (Adjusted R Squared = 0.169).
  4. cR Squared = 0.220 (Adjusted R Squared = 0.159).
  5. dR Squared = 0.234 (Adjusted R Squared = 0.174).
  6. eR Squared = 0.156 (Adjusted R Squared = 0.089).
  7. fR Squared = 0.163 (Adjusted R Squared = 0.097).
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