Table 5 Generalized linear model analysis of the relationship between the BDNF Val66Met genotype, serum BDNF and ACR score according to DPMS efficiency and quality of life due to fibromyalgia symptoms (n = 42).

From: Functional connectivity response to acute pain assessed by fNIRS is associated with BDNF genotype in fibromyalgia: an exploratory study

 

β

SE

CI 95%

Wald χ2

df

Sig

Dependent variable: Change on Numerical Pain Scale (NPS0-10) during conditioned pain modulation test

Intercept

2.103

1.9808

(− 1.780 to 5.985)

1.127

1

0.288

BDNF Val/Val (n = 30)

1.419

0.6931

(0.061 to 2.778)

4.191

1

0.041

BDNF Val/Met (n = 12)

0Reference

     

Serum BDNF (ng/ml)

 − 0.028

0.0132

(− 0.054 to 0.002)

4.393

1

0.036

ACR score

 − 0.155

0.0811

(− 0.314 to 0.004)

3.666

1

0.056

Dependent variable: Fibromyalgia Impact Questionnaire

Intercept

6.635

15.5828

(-23.907 to 37.177)

0.181

1

0.670

BDNF Val/Val (n = 30)

6.895

5.2733

(-3.440 to 17.231)

1.710

1

0.191

BDNF Val/Met (n = 12)

0Reference

     

Serum BDNF (ng/ml)

0.084

0.1035

(-0.119 to 0.287)

0.656

1

0.418

ACR score

2.325

0.6415

(1.068 to 3.582)

13.135

1

0.0003

  1. Df degrees of freedom. χ2 Wald Chi-Square. CI confidence interval. β regression coefficient. SE standard error. Sig. p-value. BDNF brain-derived neurotrophic factor. ACR American College of Rheumatology Val/Val Val66Val homozygous. Val/Met Val66Met heterozygous.
  2. The Cramer’s V was used as a measure of effect size for qui-square tests. The size effect was interpreted as follows: Standards for interpreting Cramer’s V as proposed by Cohen (1988) are the following: DF (degrees of freedom) = 1 (0.10 = small effect) (0.30 = medium effect) (0.50 = large effect). https://www.campbellcollaboration.org/escalc/html/EffectSizeCalculator-R5.php.
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