Figure 1

The expression level of HK2 gene in different tumors and pathological stages. (a) The expression status of the HK2 gene in different cancers or specific cancer subtypes was analyzed through TIMER2. * P < 0.05; ** P < 0.01; *** P < 0.001. (b) For the type of ACC, LGG, THYM, and UCS in the TCGA project, the corresponding normal tissues of the GTEx database were included as controls. The box plot data were supplied. ** P < 0.01. (c) The expression level of HK2 total protein based on the CPTAC dataset between normal tissue and primary tissue of breast cancer, KIRC, colon cancer, LUAD, ovarian cancer, and UCEC. *** P < 0.001. (d) The expression level of HK2 protein based on the HPA database between normal tissue and primary tissue of breast cancer, renal cancer, colon cancer, lung cancer, ovarian cancer, and endometrial cancer. (e) Based on the TCGA data, the expression levels of the HK2 gene were analyzed by the main pathological stages (stage I, stage II, stage III, and stage IV) of CESC, KICH, LIHC, ovarian cancer, and PAAD. Log2 (TPM + 1) was applied for the log-scale.