Table 1 Cytotoxic activity of tetrahydroquinoline derivatives against various cancer and normal cells presented as an IC50value referring to the concentration that inhibits 50% of cell growth.
Compound | Cell lines | |||||
|---|---|---|---|---|---|---|
HCT-116 | A549 | MCF-7 | HepG2 | Hela | HEK293 | |
IC50 (µM) | ||||||
5 | 13.10 ± 0.96 | > 50 | > 50 | > 50 | > 50 | > 50 |
4a | 12.18 ± 1.61**** | 11.33 ± 0.67**** | > 50 | > 50 | > 50 | 49.01 ± 2.21 |
6 | 15.61 ± 1.29 | 40.18 ± 0.94 | > 50 | > 50 | 50 | > 50 |
4b | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
4c | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
4d | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
4e | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |
5-FU | 5.78 ± 0.38**** | 8.12 ± 1.01*** | 8.41 ± 0.98** | 13.12 ± 0.32* | 11.09 ± 1.53* | 16.82 ± 0.34 |
ETP | 0.39 ± 0.01ns | 0.54 ± 0.21ns | 0.83 ± 0.15ns | 5.01 ± 0.22ns | 3.40 ± 0.51ns | 1.91 ± 0.97 |
