Table 2 Hispanic proportion estimates overall, by phase, multi-institutional status, tier assessment, masking, and year.

From: Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis

 

Frequency (%), studies

Total number of participants

Estimated proportion (95% CI)

P-value compared to reference category (*)

P-value compared to

2010 Census proportion (14.2%)

\({I}^{2}\)(%)

Hispanic

Overall

11.6% (10.8–12.4)

 < 0.0001

97.3%

Phase

II*

704 (66.3%)

74,942

10.6% (9.63–11.6)

 < .0001

97.3%

III

358 (33.7%)

182,845

13.5% (12.0–15.0)

0.0012

0.97

Institution status

Single*

414 (39.0%)

85,147

10.8% (9.51–12.2)

0.0001

97.3%

Multi-institutional

648 (61.0%)

172,640

12.1% (11.0–13.1)

0.14

0.0093

Tier assessment

1*

371 (34.9%)

19,709

10.3% (8.96–11.7)

 < .0001

97.3%

2

691 (65.1%)

238,078

12.2% (11.2–13.3)

0.030

0.017

Masking

No masking*

218 (20.5%)

40,976

10.3% (8.61–12.1)

0.0008

97.2%

Single

73 (6.87%)

18,956

11.1% (8.17–14.3)

0.67

0.14

Double

259 (24.4%)

57,691

11.0% (9.42–12.7)

0.57

0.0039

Triple

198 (18.6%)

61,581

13.6% (11.6–15.7)

0.016

0.93

Quadruple

314 (29.6%)

78,583

11.9% (10.4–13.4)

0.19

0.041

Study start year

2008*

76 (7.16%)

22,365

9.14% (6.57–12.1)

0.0041

97.0%

2009

87 (8.19%)

21,394

8.75% (06.37–11.4)

0.84

0.0008

2010

85 (8.00%)

41,081

11.8% (9.08–14.8)

0.19

0.27

2011

99 (9.32%)

12,522

9.52% (7.19–12.1)

0.84

0.0032

2012

105 (9.89%)

25,760

10.3% (7.92–12.9)

0.55

0.015

2013

125 (11.8%)

27,190

11.1% (8.81–13.5)

0.30

0.049

2014

121 (11.4%)

19,701

10.3% (8.13–12.7)

0.52

0.010

2015

121 (11.4%)

24,943

12.2% (9.81–14.7)

0.11

0.30

2016

112 (10.6%)

35,195

18.7% (15.8–21.7)

 < .0001

0.0003

2017

92 (8.66%)

16,547

13.5% (10.7–16.6)

0.034

0.99

2018

27 (2.54%)

8175

14.1% (9.10–19.9)

0.096

0.83

2019

12 (1.13%)

2914

10.2% (3.89–18.7)

0.80

0.41