Table 3 American Indian and Alaska Native proportion estimates overall, by phase, multi-institutional status, tier assessment, masking, and year.

From: Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis

 

Frequency (%), studies

Total number of participants

Estimated proportion (95% CI)

P-value compared to reference category (*)

P-value compared to

2010 Census proportion (1.10%)

\({I}^{2}\)(%)

American Indian and Alaska Native

Overall

0.19% (0.15–0.23)

 < 0.0001

78.5%

Phase

II*

1094 (68.9%)

103,813

0.13% (0.10–0.18)

 < .0001

78.2%

III

495 (31.2%)

220,155

0.30% (0.23–0.38)

 < .0001

 < .0001

Institution status

Single*

682 (42.9%)

102,520

0.09% (0.05–0.14)

 < .0001

77.9%

Multi-institutional

907 (57.1%)

221,448

0.26% (0.21–0.31)

 < .0001

 < .0001

Tier assessment

1*

824 (51.9%)

57,943

0.09% (0.05–0.13)

 < .0001

78.0%

2

765 (48.1%)

266,025

0.29% (0.23–0.35)

 < .0001

 < .0001

Masking

No masking*

341 (21.5%)

55,000

0.20% (0.12–0.29)

 < .0001

78.0%

Single

107 (6.73%)

22,081

0.13% (0.03–0.27)

0.357

 < .0001

Double

389 (24.5%)

79,017

0.17% (0.11–0.25)

0.645

 < .0001

Triple

287 (18.1%)

72,527

0.22% (0.13–0.32)

0.746

 < .0001

Quadruple

465 (29.3%)

95,343

0.20% (0.14–0.28)

0.981

 < .0001

Study start year

2008*

121 (7.61%)

35,685

0.13% (0.04–0.26)

 < .0001

77.5%

2009

156 (9.82%)

30,239

0.27% (0.15–0.43)

0.135

 < .0001

2010

134 (8.43%)

45,381

0.22% (0.10–0.38)

0.337

 < .0001

2011

145 (9.13%)

17,765

0.14% (0.05–0.27)

0.891

 < .0001

2012

159 (10.0%)

29,668

0.24% (0.12–0.39)

0.219

 < .0001

2013

189 (11.9%)

32,347

0.11% (0.04–0.21)

0.639

 < .0001

2014

169 (10.6%)

25,349

0.17% (0.08–0.30)

0.616

 < .0001

2015

177 (11.1%)

29,085

0.31% (0.18–0.48)

0.0525

 < .0001

2016

150 (9.44%)

41,432

0.19% (0.09–0.32)

0.490

 < .0001

2017

128 (8.06%)

23,619

0.14% (0.05–0.29)

0.868

 < .0001

2018

47 (2.96%)

10,243

0.20% (0.04–0.49)

0.545

 < .0001

2019

14 (0.88%)

3155

0.20% (0.00–0.87)

0.737

0.0156