Table 5 Native Hawaiian and Pacific Islander proportion estimates overall, by phase, multi-institutional status, tier assessment, masking, and year.

From: Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis

 

Frequency (%), studies

Total number of participants

Estimated proportion (95% CI)

P-value compared to reference category (*)

P-value compared to

2010 Census proportion (0.20%)

\({I}^{2}\)(%)

Native Hawaiian and Pacific Islander

Overall

0.76% (0.71–0.82)

 < 0.0001

31.3%

Phase

II*

1094 (68.9%)

103,813

1.03% (0.95–1.12)

 < .0001

30.1%

III

495 (31.2%)

220,155

0.46% (0.41–0.52)

 < .0001

 < .0001

Institution status

Single*

682 (42.9%)

102,520

1.15% (1.03–1.29)

 < .0001

30.1%

Multi-institutional

907 (57.1%)

221,448

0.60% (0.55–0.65)

 < .0001

 < .0001

Tier assessment

1*

824 (51.9%)

57,943

1.21% (1.09–1.33)

 < .0001

30.9%

2

765 (48.1%)

266,025

0.53% (0.48–0.58)

 < .0001

 < .0001

Masking

No masking*

341 (21.5%)

55,000

0.75% (0.64–0.87)

 < .0001

29.0%

Single

107 (6.73%)

22,081

1.08% (0.83–1.39)

0.0171

 < .0001

Double

389 (24.5%)

79,017

0.69% (0.60–0.79)

0.472

 < .0001

Triple

287 (18.1%)

72,527

0.84% (0.71–0.98)

0.317

 < .0001

Quadruple

465 (29.3%)

95,343

0.74% (0.66–0.84)

0.978

 < .0001

Study start year

2008*

121 (7.61%)

35,685

0.66% (0.52–0.85)

 < .0001

28.1%

2009

156 (9.82%)

30,239

0.59% (0.47–0.74)

0.473

 < .0001

2010

134 (8.43%)

45,381

0.80% (0.63–1.00)

0.292

 < .0001

2011

145 (9.13%)

17,765

0.78% (0.62–0.98)

0.359

 < .0001

2012

159 (10.0%)

29,668

0.84% (0.68–1.04)

0.151

 < .0001

2013

189 (11.9%)

32,347

0.75% (0.61–0.92)

0.898

 < .0001

2014

169 (10.6%)

25,349

0.94% (0.76–1.15)

0.0367

 < .0001

2015

177 (11.1%)

29,085

0.85% (0.70–1.05)

0.127

 < .0001

2016

150 (9.44%)

41,432

0.66% (0.54–0.81)

0.968

 < .0001

2017

128 (8.06%)

23,619

0.75% (0.59–0.95)

0.505

 < .0001

2018

47 (2.96%)

10,243

0.87% (0.59–1.30)

0.245

 < .0001

2019

14 (0.88%)

3155

0.88% (0.45–1.73)

0.439

0.0074