Table 8 Multiracial proportion estimates overall, by phase, multi-institutional status, tier assessment, masking, and year.

From: Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis

 

Frequency (%), studies

Total number of participants

Estimated proportion (95% CI)

P-value compared to reference category (*)

P-value compared to

2010 Census proportion (1.56%)

\({I}^{2}\)(%)

Multiracial

Overall

0.25% (0.21–0.31)

 < 0.0001

83.9%

Phase

II*

1094 (68.9%)

103,813

0.25% (0.19–0.32)

 < .0001

83.8%

III

495 (31.2%)

220,155

0.26% (0.18–0.35)

0.894

 < .0001

Institution status

Single*

682 (42.9%)

102,520

0.40% (0.30–0.51)

 < .0001

83.5%

Multi-institutional

907 (57.1%)

221,448

0.19% (0.14–0.24)

0.0001

 < .0001

Tier assessment

1*

824 (51.9%)

57,943

0.25% (0.18–0.33)

 < .0001

83.9%

2

765 (48.1%)

266,025

0.26% (0.20–0.33)

0.855

 < .0001

Masking

No masking*

341 (21.5%)

55,000

0.18% (0.10–0.29)

 < .0001

83.5%

Single

107 (6.73%)

22,081

0.27% (0.11–0.51)

0.571

 < .0001

Double

389 (24.5%)

79,017

0.22% (0.14–0.32)

0.593

 < .0001

Triple

287 (18.1%)

72,527

0.37% (0.24–0.52)

0.0248

 < .0001

Quadruple

465 (29.3%)

95,343

0.27% (0.19–0.38)

0.176

 < .0001

Study start year

2008*

121 (7.61%)

35,685

0.23% (0.09–0.42)

 < .0001

83.1%

2009

156 (9.82%)

30,239

0.20% (0.08–0.35)

0.756

 < .0001

2010

134 (8.43%)

45,381

0.24% (0.11–0.44)

0.901

 < .0001

2011

145 (9.13%)

17,765

0.16% (0.05–0.31)

0.491

 < .0001

2012

159 (10.0%)

29,668

0.36% (0.20–0.57)

0.302

 < .0001

2013

189 (11.9%)

32,347

0.26% (0.13–0.43)

0.512

 < .0001

2014

169 (10.6%)

25,349

0.29% (0.15–0.48)

0.606

 < .0001

2015

177 (11.1%)

29,085

0.30% (0.16–0.49)

0.555

 < .0001

2016

150 (9.44%)

41,432

0.26% (0.13–0.44)

0.805

 < .0001

2017

128 (8.06%)

23,619

0.17% (0.05–0.34)

0.570

 < .0001

2018

47 (2.96%)

10,243

0.60% (0.25–1.11)

0.0772

 < .0001

2019

14 (0.88%)

3155

0.22% (0.00–1.04)

0.980

0.0053