Figure 1 | Scientific Reports

Figure 1

From: Structural informatic study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water-soluble QTY variants

Figure 1The alternative text for this image may have been generated using AI.

Protein alignments of six solute carrier transporters with their QTY variants. The symbols | and * indicate the identical and different amino acids, respectively. Please note the Q, T and Y amino acid replacement (red). The alpha-helices (blue) are shown above the protein sequences. The loop color codes are: internal (yellow) and external (red). Features of natural and QTY variants are: molecular weight, pI, total variation % and transmembrane variation %. The alignments are: (a) SLC2A1 versus SLC2A1QTY, (b) SLC7A11 versus SLC7A11QTY, (c) SLC4A4 versus SLC4A4QTY, (d) SLC1A5 versus SLC1A5QTY, (e) SLC7A5 versus SLC7A5QTY, (f) SLC29A1 versus SLC29A1QTY. Although there are significant QTY changes for the TM alpha-helix changes, > 45% for SLC29A1, > 50% for SLC7A11, their changes of molecular weight and pI are insignificant (Table 2).

Back to article page