Figure 3

Superposed 6 solute carrier transporter crystal or CryoEM structures with QTY variants predicted by AlphaFold2. The X-ray crystal or CryoEM structures of the native transporters are obtained from the Protein Data Bank (PDB). The crystal or CryoEM structures (magenta) are superposed with QTY variants (cyan) predicted by AlphaFold2. The RMSD (Å) for each structure is in Table 2. (a) SLC2A1^Crystal versus SLC2A1^QTY (2.281 Å), (b) SLC7A11^CryoEM versus SLC7A11^QTY (0.933 Å), (c) SLC4A4^CryoEM versus SLC4A4^QTY (0.445 Å), (d) SLC1A5^Crystal versus SLC1A5^QTY (0.965 Å), (e) SLC7A5^CryoEM versus SLC7A5^QTY (1.815 Å), (f) SLC29A1^Crystal versus SLC29A1^QTY (1.512 Å). These superposed structures display that the crystal or CryoEM structures and their QTY variants have very similar molecular structures (Tables 2, 3). For clarity of direct comparisons, the N-terminus and C-terminus are deleted.