Figure 4

Superposed 7 native solute carrier transporters and their QTY variants that were predicted by AlphaFold2. The native structures (green) and their water-soluble QTY variants (cyan). For the superposed structures, the RMSD is in Å ( ). (a) SLC39A6 versus SLC39A6QTY (0.931 Å) (b) SLC39A3 versus SLC39A3QTY (1.567 Å), (c) SLC9A1 versus SLC9A1QTY (0.905 Å), (d) SLC6A14 versus SLC6A14QTY (0.521 Å), (e) SLC4A7 versus SLC4A7QTY (0.426 Å), (f) SLC5A8 versus SLC5A8QTY (1.593 Å), (g) SLC41A1 versus SLC41A1QTY (1.914 Å). The large N- and C-termini are removed for clarity. Please see Tables 2 and 3. For clarity, N-terminus, C-terminus and large loops are deleted.