Table 1 The solute carrier transporters relevant in pancreatic cancer.

From: Structural informatic study of determined and AlphaFold2 predicted molecular structures of 13 human solute carrier transporters and their water-soluble QTY variants

Transporter

Cancer characteristics

Transporter substrates

1) SLC2A1

Metastasis/Cellular metabolism

Glucose and other sugars

2) SLC7A11

Metastasis/Cell death/Proliferation/Chemo-sensitivity

Cysteine, Glutamate

3) SLC4A4

Metastasis/Angiogenesis

Na+, HCO−

4) SLC1A5

Proliferation/Cellular metabolism/Chemo-sensitivity

Ala, Ser, Cys, Thr, Asn, Gln

5) SLC7A5

Proliferation/ Cellular metabolism

Large AA, DOPA, BCH

6) SLC29A1

Chemo-sensitivity

Nucleotides

7) SLC39A6

Metastasis/Proliferation

Zn2+

8) SLC39A3

Proliferation

Zn2+

9) SLC9A1

Metastasis

Na+, Li+, NH4+, H+,

10) SLC6A14

Programmed cell death

Neutral and cationic AA

11) SLC4A7

Proliferation

Na+, HCO−

12) SLC5A8

Proliferation

Short chain fatty acids

13) SLC41A1

Proliferation

Mg2+

  1. The Table 1 is summarized from Wu et al. (Ref1). For details, please consult the original review.
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